J. Hoffmann

Integration of ζ-deficient CARs into the CD3-zeta gene conveys potent cytotoxicity in T and NK cells

This paper develops a method to integrate ζ-deficient CARs into the CD3ζ gene to create functional CAR-T and CAR-NK cells with improved safety and efficacy for off-the-shelf therapies.

Phenotypic drought stress prediction of European beech (Fagus sylvatica) by genomic prediction and remote sensing

This study predicts phenotypic drought stress in European beech using genomic prediction and remote sensing data, showing improved explanatory power with genomic data.

DNMT3A clonal hematopoiesis-driver mutations induce cardiac fibrosis by paracrine activation of fibroblasts

This study shows that DNMT3A mutations in hematopoietic cells drive cardiac fibrosis by activating fibroblasts through paracrine signaling, contributing to heart failure progression.

Antibiofilm agents with therapeutic potential against enteroaggregative Escherichia coli

This paper identifies five compounds with significant antibiofilm activity against enteroaggregative Escherichia coli, with one targeting the EAEC anti-aggregation protein dispersin.

In-depth immunophenotyping with mass cytometry during TB treatment reveals non-canonical T-cell subsets associated with sputum culture conversion.

The paper uses mass cytometry to analyze T-cell subsets in TB patients, finding specific immune profiles linked to sputum culture conversion during treatment.

Breaking the Crosstalk of the Cellular Tumorigenic Network in NSCLC by a Highly Effective Drug Combination

This study shows a low-dose drug combination effectively suppresses NSCLC PDX tumors with high response and complete remission rates.

A SARS-CoV-2 neutralizing antibody protects from lung pathology in a COVID-19 hamster model

This study identifies a potent SARS-CoV-2 neutralizing antibody that protects hamsters from infection and lung damage.

Effects of Post-Myocardial Infarction Heart Failure on the Bone Vascular Niche

This study investigates how post-myocardial infarction heart failure affects the bone vascular niche, showing age-independent loss of type H endothelium and increased inflammatory gene expression in human bone marrow endothelium.

Rifampicin exposure reveals within-host Mycobacterium tuberculosis diversity in patients with delayed culture conversion

The paper analyzes genetic diversity in Mycobacterium tuberculosis isolates from TB patients with delayed culture conversion, revealing drug-tolerant sub-populations and their potential role in treatment failure.

Dietary vs non-dietary fatty acid profiles of lake trout ecotypes from Lake Superior and Great Bear Lake: Are fish really what they eat?

The paper examines non-dietary fatty acid profiles in lake trout ecotypes to assess their ability to distinguish intraspecific diversity across lakes and ecotypes.

Light-driven formation of high-valent manganese oxide by photosystem II supports evolutionary role in early bioenergetics

The paper shows modern photosystem II can form birnessite-type Mn oxides, suggesting an evolutionary link between ancient Mn oxide production and current water oxidation mechanisms.

Size, shape and structure of insect wings

The paper analyzes insect wing morphology across multiple dimensions to define morphospaces and explore diversity across insect orders.