Cell BiologybioRxiv
Imbalance between IL-36 receptor agonist and antagonist drives neutrophilic inflammation in COPD
J. R. Baker, P. S. Fenwick, C. K. Coss…·L. E. Donnelly
The paper identifies an imbalance between IL-36 receptor agonist and antagonist in COPD patients, showing it drives neutrophilic inflammation and suggests a therapeutic antibody targeting IL-36R as a potential treatment.
DOI 10.1172/jci.insight.155581