Author

H. Costa

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 3 Ecology· 1

Signature Assays, Organisms & Methods

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Approach:statistical model· 4 Research Focus:differential expression· 3 Research Focus:gene regulatory network inference· 3 Organism:human· 3 Assay:whole-genome sequencing· 3 Assay:ATAC-seq· 2 Assay:bulk RNA-seq· 2 Approach:deep learning· 2

Frequent Co-Authors

A. Berner· 3 shared A. Sottoriva· 3 shared A.-M. Baker· 3 shared B. Chen· 3 shared C. James· 3 shared C. Kimberley· 3 shared C. Lynn· 3 shared D. Nichol· 3 shared

Activity by Year

2020-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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3 shared papersCancer Biology

A. Berner

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Phenotypic plasticity and genetic control in colorectal cancer evolution

J. Househam, T. Heide, G. D. Cresswell, C. Lynn, I. Spiteri, M. Mossner, C. Kimberley, C. Gabbutt, E. Lakatos, A. Berner, M. Schmidt, A.-M. Baker, J. Fernandez-Mateos, B. Chen, L. Zapata, , T. A. Graham

This study investigates phenotypic plasticity and genetic control in colorectal cancer by analyzing gene expression and genetic variation across multiple tumor regions.

Nature · Oct 26, 2022Peer-reviewedCancer Biology

The co-evolution of the genome and epigenome in colorectal cancer

T. Heide, J. Househam, I. Spiteri, C. Lynn, G. D. Cresswell, M. Mossner, C. Kimberley, J. Fernandez-Mateos, B. Chen, L. Zapata, C. James, I. Barozzi, K. Chkhaidze, D. Nichol, A. Berner, , A. Sottoriva

This study examines the co-evolution of genome and epigenome in colorectal cancer using single-clone spatial multi-omic profiling, revealing epigenetic changes and their impact on mutation accumulation.

Nature · Oct 26, 2022Peer-reviewedCancer Biology

Assessment of the evolutionary consequence of putative driver mutations in colorectal cancer with spatial multiomic data

T. Heide, J. Househam, G. D. Cresswell, I. Spiteri, C. Lynn, C. Kimberley, M. Mossner, L. Zapata, C. Gabbutt, D. Ramazzotti, B. Chen, J. Fernandez-Mateos, C. James, F. Iorio, A. Berner, , A. Sottoriva

This study uses spatial multiomic data to assess the evolutionary impact of putative driver mutations in colorectal cancer, identifying both genetic and non-genetic factors influencing subclonal expansion.

bioRxiv · Jul 14, 2021 · PreprintCancer Biology

Modification of forests by people means only 40% of remaining forests have high ecosystem integrity

H. S. Grantham, A. Duncan, T. D. Evans, K. R. Jones, H. Beyer, R. Schuster, J. Walston, J. Ray, J. Robinson, M. Callow, T. Clements, H. Costa, A. DeGemmis, P. R. Elsen, J. Ervin, , S. Wang

The paper quantifies global forest modification, finding 40.5% of remaining forests have high ecosystem integrity, mostly in specific regions, and highlights the need for policies to protect these areas.

bioRxiv · Mar 5, 2020 · PreprintEcology