Author

H. Dejakaisaya

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Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Assay:cryo-EM· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Organism:human· 1

Frequent Co-Authors

B. A. Cole· 1 shared C. W. G. Fishwick· 1 shared J. D. Lippiat· 1 shared N. Pilati· 1 shared R. M. Johnson· 1 shared S. P. Muench· 1 shared

Activity by Year

2019-2019 · peak 1/yr

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6 top collaborators · 15 mutual co-author links

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1 shared paperPharmacology & Toxicology

B. A. Cole

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1 paper

Recent·Most cited

Pharmacology & ToxicologybioRxivSep 26, 2019

Structure-based identification and characterisation of novel inhibitors of KNa1.1 potassium channels, a stratified target for KCNT1-related epilepsy.

B. A. Cole, R. M. Johnson, H. Dejakaisaya…·J. D. Lippiat

This study identifies novel inhibitors of KNa1.1 potassium channels using cryo-EM structures and computational methods, showing improved potency over quinidine for KCNT1-related epilepsy treatment.

DOI 10.1016/j.isci.2020.101100

humancryo-EM

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