S. P. Muench

This paper uses time-resolved cryoEM to directly observe the swinging lever mechanism of myosin-5, showing its structural changes during ATP hydrolysis and force generation.

This study shows that the bacterial magnesium transporter MgtA has functional specificity for cardiolipin species, with maximum activity achieved when combining cardiolipin 16:0 and 18:1.

This paper identifies a molecular switch in the RCK2 domain of KNa1.1 channels that mediates sodium-dependent activation through conformational changes involving specific amino acid residues.

This paper isolates and characterizes Affimers, antibody-like proteins, that inhibit influenza A virus H3 subtype infection in vitro and block HA-receptor interactions.

This study uses cryo-EM and molecular dynamics to determine the structure and physical properties of Myo5a's lever, revealing its working stroke and implications for its walking mechanism.

This study identifies a direct interaction between CDK1 and talin at integrin adhesions, showing CDK1 modulates talin's mechanosensitivity and affects downstream mechanotransduction.

This study examines how different macromolecular complexes behave during cryoEM grid preparation at various timescales using three vitrification devices.

This study identifies novel inhibitors of KNa1.1 potassium channels using cryo-EM structures and computational methods, showing improved potency over quinidine for KCNT1-related epilepsy treatment.

This paper introduces a cryo-EM grid preparation device that enables rapid mixing and vitrification, achieving sub 4 Å reconstructions for time-resolved structural studies.