H. Donahue

This study shows that hindlimb unloading causes age-dependent changes in bone microarchitecture and gene expression in mice, with younger mice showing senescence pathway activation and older mice showing mitochondrial dysfunction.

This study shows that different mouse strains respond variably to limb immobilization, with distinct effects on body weight, activity, food consumption, and muscle gene expression.

This study shows that mechanical loading of bone during re-ambulation recovers bone but not muscle lost during hind limb suspension in mice.