Author

H. Dopeso

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 3

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 3 Approach:experimental assay· 3 Research Focus:cancer & tumor microenvironment· 2 Research Focus:cell type annotation· 2 Organism:human· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:differential expression· 1 Assay:DNA methylation· 1

Frequent Co-Authors

B. Weigelt· 2 shared E. M. Da Silva· 2 shared A. Gazzo· 1 shared A. L. F. Longhini· 1 shared A. Nasrazadani· 1 shared A. V. Lee· 1 shared B. D. Greenbaum· 1 shared C. G. Kleer· 1 shared

Activity by Year

2023-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 22 mutual co-author links

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2 shared papersCancer Biology

B. Weigelt

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Spatial molecular profiling of mixed invasive ductal-lobular breast cancers reveals heterogeneity in intrinsic molecular subtypes, oncogenic signatures, and mutations

O. S. Shah, A. Nasrazadani, J. Foldi, J. M. Atkinson, C. G. Kleer, P. F. McAuliffe, T. J. Johnston, W. Stallaert, E. M. Da Silva, P. Selenica, H. Dopeso, F. Pareja, D. Mandelker, B. Weigelt, J. S. Reis-Filho, , S. Oesterreich

This study uses spatial molecular profiling to show that mixed invasive ductal-lobular breast cancers have distinct molecular subtypes, oncogenic signatures, and mutations in different tumor regions, leading to prognostic uncertainty and therapeutic challenges.

bioRxiv · Sep 9, 2023Cancer Biology

Interferon response and epigenetic modulation by SMARCA4 mutations drive ovarian tumor immunogenicity

M. N. Brodeur, H. Dopeso, Y. Zhu, A. L. F. Longhini, A. Gazzo, S. Sun, R. Koche, R. Qu, P.-J. Hamard, Y. Bykov, H. Green, K. B. Chiappinelli, M. A. Ozsoy, T. Basili, R. Gardner, , D. Zamarin

This study shows that SMARCA4 mutations in ovarian cancer increase immunogenicity through interferon response and epigenetic changes, enhancing T cell and NK cell activity in the tumor microenvironment.

bioRxiv · Aug 8, 2023 · PreprintCancer Biology

FOXK2 amplification and overexpression promotes breast cancer development and chemoresistance

Y. Yu, W.-M. Cao, F. Cheng, Z. Shi, L. Han, J.-L. Yi, E. M. da Silva, H. Dopeso, H. Chen, J. Yang, X. Wang, C. Zhang, H. Zhang

This study identifies FOXK2 amplification and overexpression in breast cancer, showing its role in promoting tumor growth, chemoresistance, and synergistic therapeutic responses when targeted with PI3KCA inhibitors.

bioRxiv · May 28, 2023 · PreprintCancer Biology