F. Cheng

A Molecular Image-based Explainable Artificial intelligence Framework Identifies Novel Candidate Antibiotics

This paper presents an explainable AI framework using molecular images to identify novel antibiotic candidates from FDA-approved drugs.

γ-aminobutyric acid receptor B signaling drives glioblastoma in females in an immune-dependent manner

This study shows GABA receptor B signaling promotes GBM growth in females through immune mechanisms, with sex-specific effects on survival and treatment outcomes.

Investigation of the mechanism of accelerated biodegradation of Paracoccus-KDSPL-02

This study identifies PROKKA_01468 as a photoreceptor protein in Paracoccus-KDSPL-02 that enhances penicillin G degradation under light.

CAMKV Kinase Signaling Is a Novel Therapeutic Avenue with Prognostic Relevance in Neuroblastoma

This study identifies CAMKV kinase signaling as a critical driver of neuroblastoma growth and shows it as a potential therapeutic target and prognostic marker.

Molecular dynamics simulations reveal molecular mechanisms for the gain and loss of function effects of four SCN2A variants

The paper uses molecular dynamics simulations to analyze four SCN2A variants, revealing how they affect channel structure and function, with R937C being the most unstable.

CRISPR-repressed toxin-antitoxin provides population-level immunity against diverse anti-CRISPR elements

The paper identifies a CRISPR-repressed toxin that provides population-level immunity against diverse anti-CRISPR elements by expelling them through abortive infection-like effects.

Gene and allele specific expression underlying the electric signal divergence in African weakly electric fish

The paper identifies gene and allele-specific expression patterns underlying electric signal divergence in African weakly electric fish, highlighting cis-regulatory differences in KCNJ2 and KLF5.

Proteomic Stratification of Prognosis and Treatment Options for Small Cell Lung Cancer

This study uses proteomic profiling to stratify small cell lung cancer into three subtypes with distinct clinical outcomes and treatment responses, identifying potential therapeutic targets and improving prognosis prediction.

Identification of Host Restriction Factors Critical for Recombinant AAV Transduction of Polarized Human Airway Epithelium

This study identifies host restriction factors critical for rAAV2.5T transduction of polarized human airway epithelium, revealing KIAA0319L's role in transduction but not internalization, and WDR63's role in transduction without involvement in internalization or nuclear entry.

Engineering cGAS-agonistic oligonucleotides as therapeutics and vaccine adjuvants for cancer immunotherapy

This paper develops Svg3, a cGAS-agonistic oligonucleotide, showing enhanced IFN-I responses and improved immunotherapy efficacy in preclinical models.

Phenotypic Switching of Vascular Smooth Muscle Cells in Duchenne Muscular Dystrophy

This study investigates how dystrophin deficiency in vascular smooth muscle cells (VSMCs) leads to phenotypic switching and mitochondrial dysfunction in DMD, identifying potential transcription factors involved.

FOXK2 amplification and overexpression promotes breast cancer development and chemoresistance

This study identifies FOXK2 amplification and overexpression in breast cancer, showing its role in promoting tumor growth, chemoresistance, and synergistic therapeutic responses when targeted with PI3KCA inhibitors.

Degenerated CRISPRs widely regulate Cas expression to balance immunity and cost

The paper shows degenerated CRISPRs encode regulatory RNAs that autoregulate Cas protein expression, balancing immunity and host fitness costs.

Identification and functional validation of human islet microRNAs associated with donor trait

The paper identifies human islet microRNAs associated with donor traits and validates their functional role in telomere length and cellular senescence.

TRAF6 modulates PD-L1 expression through YAP1-TFCP2 signaling in melanoma

This study identifies TRAF6 as a regulator of PD-L1 expression in melanoma through YAP1-TFCP2 signaling, showing TRAF6 inhibition enhances anti-tumor immunity.

Horizontal mitochondrial transfer from the microenvironment increases glioblastoma tumorigenicity

The paper identifies horizontal mitochondrial transfer from astrocytes to glioblastoma cells as a mechanism that enhances tumorigenicity by improving mitochondrial function and metabolic capacity.

Engineered small extracellular vesicles as a FGL1/PD-L1 dual-targeting delivery system for alleviating immune rejection

This study develops engineered small extracellular vesicles targeting FGL1 and PD-L1 to suppress immune rejection in transplantation by inhibiting T cell activation and improving graft survival.

AGL16 regulates genome-wide gene expression and flowering time with partial dependency on SOC1 in Arabidopsis

This study identifies AGL16's role in regulating gene expression and flowering time in Arabidopsis, showing partial dependency on SOC1 and involvement in water loss and seed dormancy.

Cytoskeletal vimentin regulates cell size and autophagy through mTORC1 signaling

This study shows vimentin regulates cell size and autophagy via mTORC1 signaling, with effects observed in both cell and organism levels.

All-Flesh Tomato Regulated by Reduced Dosage of AFF Provides New Insights into Berry Fruit Evolution

The study identifies a 416-bp deletion in the AFF gene's promoter that reduces its expression, leading to all-flesh tomato fruits and providing insights into berry fruit evolution.

Vimentin provides target search efficiency and mechanical resilience for dendritic cell migration

This study shows vimentin enhances dendritic cell migration through confined spaces by improving mechanical resilience and target search efficiency.

Establishment of a Replicon System for Bourbon Virus and Identification of Small Molecules that Efficiently Inhibit Virus Replication

This study establishes a BRBV replicon system and identifies myricetin as a potent inhibitor of BRBV replication with a high therapeutic index.

Myeloid-derived suppressor cell subsets drive glioblastoma growth in a sex-specific manner

This study identifies sex-specific roles of MDSC subsets in glioblastoma, showing mMDSCs drive growth in males and gMDSCs in females, with potential therapeutic targets.

Branched chain amino acid aminotransferase 2 Regulates Ferroptotic Cell Death in Cancer Cells

This study identifies BCAT2 as a suppressor of ferroptosis in cancer cells, showing its role in regulating glutamate levels and enhancing resistance to ferroptosis-inducing therapies.

Vimentin provides the mechanical resilience required for amoeboid migration and protection of the nucleus.

This study shows vimentin, along with actin, provides mechanical resilience for amoeboid migration and protects the nucleus from DNA damage in confined spaces.

Seasonal diets overwhelm host species in shaping the gut microbiota of Yak and Tibetan sheep

This study compares gut microbiota of yaks and Tibetan sheep, finding that seasonal diet has a greater impact than host species on microbiota composition.

Gene markers for exon capture and phylogenomics in ray-finned fishes

The paper identifies and validates single-copy gene markers for phylogenomic studies in ray-finned fishes using comparative genomics and empirical testing across 83 species.