Author

H. Elcocks

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 3

Signature Assays, Organisms & Methods

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Research Focus:cell signaling & trafficking· 3 Organism:human· 3 Assay:proteomics· 3 Approach:experimental assay· 2 Research Focus:cell type annotation· 1 Research Focus:drug response / drug discovery· 1 Approach:genetic perturbation / CRISPR· 1 Research Focus:host-pathogen & immune response· 1

Frequent Co-Authors

M. J. Clague· 3 shared S. Urbe· 3 shared H. J. Mortiboys· 2 shared K. R. McCarron· 2 shared A. Behrens· 1 shared A. Clancy· 1 shared A. J. Brazel· 1 shared A. Kallinos· 1 shared

Activity by Year

2020-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 30 mutual co-author links

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3 shared papersCell Biology

M. J. Clague

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Author profile →

3 papers

Recent·Most cited

The Parkinson's Disease related mutant VPS35 (D620N) amplifies the LRRK2 response to endolysosomal stress

K. R. McCarron, H. Elcocks, H. J. Mortiboys, S. Urbe, M. J. Clague

This study shows that the VPS35 D620N mutation enhances LRRK2 activity and amplifies its response to endolysosomal stress, leading to increased phosphorylation of RAB10 and RAB12.

bioRxiv · Dec 2, 2023Cell Biology

FBXL4 deficiency promotes mitophagy by elevating NIX.

H. Elcocks, A. J. Brazel, K. R. McCarron, M. Kaulich, K. Husnjak, H. J. Mortiboys, M. J. Clague, S. Urbe

This study identifies FBXL4 as a negative regulator of basal mitophagy through NIX stabilization, showing that its deficiency promotes mitophagy and suggesting MLN4924 as a potential therapeutic agent for mitochondrial diseases.

bioRxiv · Oct 11, 2022 · PreprintCell Biology

The deubiquitylase USP9X controls ribosomal stalling

A. Clancy, C. Heride, A. Pinto-Fernandez, A. Kallinos, K. Kayser-Bricker, W. Wang, V. Smith, H. Elcocks, S. Davis, S. Fessler, C. McKinnon, M. Katz, T. Hammonds, N. P. Jones, J. O'Connell, , M. J. Clague

This study identifies USP9X as a deubiquitylase that regulates ZNF598 stability, impacting ribosomal quality control through modulation of di-ribosome resolution.

bioRxiv · Apr 15, 2020Cell Biology