Author

H. Hakonarson

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 3 Immunology· 2

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 5 Approach:experimental assay· 4 Organism:mouse· 4 Research Focus:cell signaling & trafficking· 3 Assay:bulk RNA-seq· 2 Research Focus:cancer & tumor microenvironment· 2 Organism:human· 2 Assay:scRNA-seq· 2

Frequent Co-Authors

M. Gonzalez· 3 shared M. Haldar· 2 shared S. Devalaraja· 2 shared A. Boehm· 1 shared A. DeVine· 1 shared A. Gutierrez-Uzquiza· 1 shared A. Lopez-Garcia· 1 shared A. M. Cuesta· 1 shared

Activity by Year

2020-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 16 mutual co-author links

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3 shared papersCancer Biology

M. Gonzalez

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

CRISPR/Cas9 screenings unearth protein arginine methyltransferase 7 as a novel driver of metastasis in prostate cancer

M. Rodrigo-Faus, A. Vincelle-Nieto, N. Vidal, J. Puente, M. Saiz-Pardo, A. Lopez-Garcia, M. Mendiburu-Elicabe, N. Palao, C. Baquero, A. M. Cuesta, H.-Q. Qu, H. Hakonarson, M. Musteanu, A. Reyes-Palomares, A. Porras, , A. Gutierrez-Uzquiza

This study identifies PRMT7 as a novel driver of metastasis in prostate cancer through CRISPR/Cas9 screens and validates its role in promoting cell motility and tumor dissemination.

bioRxiv · Jul 20, 2023 · PreprintCancer Biology

Human T follicular helper clones seed the germinal center-resident regulatory pool

C. Le Coz, D. A. Oldridge, R. S. Herati, N. De Luna, J. Garifallou, E. C. Cabrera, J. P. Belman, D. Pueschl, L. V. Silva, A. V. C. Knox, S. Yoon, K. B. Zur, S. D. Handler, H. Hakonarson, E. J. Wherry, , N. Romberg

The paper identifies human Tfr cells as either Treg-derived (nTfr) or Tfh-derived (iTfr) clones, with distinct functional and spatial characteristics.

bioRxiv · Oct 26, 2022Immunology

Oncogene-induced matrix reorganization controls CD8+ T cell function in the soft-tissue sarcoma microenvironment

A. M. Fuller, H. C. Pruitt, Y. Liu, V. M. Irizarry-Negron, H. Pan, H. Song, A. DeVine, R. S. Katti, S. Devalaraja, G. E. Ciotti, M. Gonzalez, E. F. Williams, I. Murazzi, D. Ntekoumes, N. Skuli, , T. S. K. Eisinger-Mathason

This study identifies YAP1-driven collagen VI deposition in sarcoma as a mechanism suppressing CD8+ T cell function through ECM remodeling and autophagy inhibition.

bioRxiv · Mar 31, 2022Cancer Biology

CSF-1 maintains pathogenic but not homeostatic myeloid cells in the central nervous system during autoimmune neuroinflammation.

D. Hwang, L. L. W. Ishiwaka, A. Boehm, Z. Sahin, G. Casella, S. Jang, M. Seyedsadr, M. V. Gonzalez, J. P. Garifallou, H. Hakonarson, G.-X. Zhang, A. Rostami, B. Ciric

This study shows that blocking CSF-1 reduces harmful myeloid cells in EAE without affecting beneficial ones, suggesting CSF-1 as a therapeutic target for MS.

bioRxiv · Oct 23, 2020Immunology

Single-cell transcriptomic profile reveals macrophage heterogeneity in medulloblastoma and their treatment-dependent recruitment

M. T. Dang, M. Gonzalez, K. S. Gaonkar, K. S. Rathi, P. Young, S. Arif, L. Zhai, M. Alam, S. Devalaraja, T. Tsun, I. Folkert, P. Raman, J. L. Rokita, D. Martinez, J. Taroni, , M. Haldar

The paper uses single-cell and bulk RNA sequencing to study macrophage heterogeneity in medulloblastoma and shows differential recruitment with targeted vs. radiation therapy.

bioRxiv · Feb 12, 2020 · PreprintCancer Biology