Oncogene-induced matrix reorganization controls CD8+ T cell function in the soft-tissue sarcoma microenvironment
A. M. Fuller, H. C. Pruitt, Y. Liu, V. M. Irizarry-Negron, H. Pan, H. Song, A. DeVine, R. S. Katti, S. Devalaraja, G. E. Ciotti, M. Gonzalez, E. F. Williams, I. Murazzi, D. Ntekoumes, N. Skuli, , T. S. K. Eisinger-Mathason
This study identifies YAP1-driven collagen VI deposition in sarcoma as a mechanism suppressing CD8+ T cell function through ECM remodeling and autophagy inhibition.
bioRxiv · Mar 31, 2022Cancer Biology