Tissue fibroblasts are a critical source of prostacyclin and anti-thrombotic
J. A. Mitchell, M. Vinokurova, M. E. Lopes-Pires, F. Shala, P. C. Armstrong, B. Ahmetaj-Shala, Y. Elghazouli, B. Liu, Y. Zhou, C. Hao, H. Herschman, N. S. Kirkby
The paper shows lung and other tissues produce prostacyclin via fibroblasts, providing systemic anti-thrombotic protection, challenging the traditional view that endothelium is the main source.
bioRxiv · Jan 11, 2022 · PreprintPharmacology & Toxicology