C. Hao

MICLEAR: Intelligent Molecular Cytology for Intraoperative Margin Assessment of Pancreatic Ductal Adenocarcinoma

MICLEAR uses Raman imaging and machine learning to assess PDAC surgical margins with high accuracy and speed.

SOCfinder: a genomic tool for identifying cooperative genes in bacteria

SOCfinder identifies cooperative genes in bacterial genomes by combining extracellular protein coding, functional annotations, and secondary metabolite biosynthesis.

Design of SARS-CoV-2 protease inhibitors with improved affinity and reduced sensitivity to mutations

This study designs a SARS-CoV-2 protease inhibitor with improved affinity and reduced mutation sensitivity compared to existing drugs.

Myostatin gene deletion alters gut microbiota stimulating fast-twitch glycolytic muscle growth

This study shows that Myostatin gene deletion in pigs alters gut microbiota, increasing SCFAs which stimulate fast-twitch glycolytic muscle growth through the Akt/mTOR pathway.

Signatures of kin selection in a natural population of the bacteria Bacillus subtilis

The paper examines a natural population of Bacillus subtilis and finds evidence supporting kin selection through higher polymorphism and divergence in cooperative traits.

Tissue fibroblasts are a critical source of prostacyclin and anti-thrombotic

The paper shows lung and other tissues produce prostacyclin via fibroblasts, providing systemic anti-thrombotic protection, challenging the traditional view that endothelium is the main source.

Miniature inverted-repeat transposable elements drive rapid microRNA diversification in angiosperms

The paper identifies MITEs as a source of new miRNAs in angiosperms, showing they rapidly diversify miRNA repertoires through transposition and transcription.

The Copper Responsive Transcription Factor SPL7 Represses Key Abscisic Acid Biosynthetic Genes to Balance Growth and Drought Tolerance

High copper availability represses SPL7, releasing its suppression on key ABA biosynthetic genes and leading to increased ABA accumulation that inhibits growth but enhances drought tolerance.

Coupling Comprehensive Transcriptome-Metabolome Association and Phylogenetic Analysis Speed Dissecion of Polyphyllins Biosynthetic Pathway

This study identifies key genes in the polyphyllin biosynthetic pathway using transcriptome and metabolome data combined with phylogenetic analysis.

Regulation of pancreatic fibrosis by acinar cell-derived exosomal miR-130a-3p via targeting of stellate cell PPAR-γ

This study identifies exosomal miR-130a-3p from acinar cells as a regulator of pancreatic fibrosis by targeting PPAR-γ in stellate cells, showing its role in collagen formation and fibrosis progression.

The PIF1-MIR408-Plantacyanin Repression Cascade Regulates Light Dependent Seed Germination

The paper identifies a PIF1-MIR408-PLC repression cascade that links light-induced PIF1 degradation to hormonal changes, regulating seed germination in Arabidopsis.

BLOS1 mediates kinesin switch during endosomal recycling of LDL receptor

This study identifies BLOS1 as a mediator of kinesin switch during LDLR endosomal recycling, showing its role in RE transport and LDL clearance.

High glucose-induced ubiquitylation of G6PD leads to the injury of podocyte

This study shows high glucose induces ubiquitylation of G6PD via VHL, leading to ROS accumulation and podocyte injury in diabetic kidney disease.