Pharmacology & ToxicologybioRxivPreprint
Rapid tolerance to morphine in the myenteric neurons of the small intestine is independent of β-arrestin-2 and mediated by PKC
K. H. Muchhala, J. C. Jacob, I. Alam…·H. I. Akbarali
This study shows that morphine tolerance in the small intestine develops rapidly and is independent of β-arrestin-2 but mediated by PKC, unlike peripheral antinociceptive tolerance.
DOI 10.1101/2020.07.17.209437