Regulation of mesenchymal stem cell function by TGFβ-1 on mast cell extracellular vesicles -- role of endosomal retention
Y. Yin, G. V. Shelke, S. C. Jang, C. Lasser, S. Wennmalm, H. J. Hoffmann, J. Nilsson, L. Li, Y. S. Gho, J. Lotvall
The paper shows that mast cell-derived extracellular vesicles carrying TGFβ-1 enhance mesenchymal stem cell migration and MMP activity, with endosomal retention prolonging TGFβ-1 signaling and reducing allergic inflammation.
bioRxiv · Aug 4, 2017Cell Biology