Cell BiologybioRxiv
Regulation of mesenchymal stem cell function by TGFβ-1 on mast cell extracellular vesicles -- role of endosomal retention
Y. Yin, G. V. Shelke, S. C. Jang…·J. Lotvall
The paper shows that mast cell-derived extracellular vesicles carrying TGFβ-1 enhance mesenchymal stem cell migration and MMP activity, with endosomal retention prolonging TGFβ-1 signaling and reducing allergic inflammation.