H. L. Ng

Development, Characterization, and Structural Analysis of a Genetically Encoded Red Fluorescent Peroxynitrite Biosensor

The paper develops a red fluorescent peroxynitrite biosensor (pnRFP) using a genetically encoded boronic acid-containing amino acid, characterizes its properties, and elucidates its sensing mechanism through structural analysis.

Targeted engagement of β-catenin-Ikaros complexes in refractory B-cell malignancies

This study identifies a unique vulnerability in B-cell malignancies where GSK3β inhibitors disrupt β-catenin-Ikaros complexes, leading to MYC repression and cell death.

Mechanisms of allosteric and mixed mode aromatase inhibitors

This study identifies four novel non-steroidal aromatase inhibitors through virtual screening, showing mixed-type and competitive inhibition with potential for improved adverse effect profiles.

Recombinant expression in E. coli of human FGFR2 with its transmembrane and extracellular domains

This study expresses a functional human FGFR2 construct in E. coli containing its transmembrane and extracellular domains, showing it binds heparin and dimerizes but does not form complexes with FGF1 or adopt an inactive dimer conformation.