Author

M. Mueschen

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Cancer Biology· 2 Immunology· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Approach:experimental assay· 3 Research Focus:cancer & tumor microenvironment· 2 Organism:mouse· 2 Assay:proteomics· 2 Research Focus:cell signaling & trafficking· 1 Organism:human· 1

Frequent Co-Authors

J. Lee· 3 shared K. Kume· 3 shared K. N. Cosgun· 3 shared L. N. Chan· 3 shared M. E. Robinson· 3 shared E. Leveille· 2 shared G. Xiao· 2 shared J. Chen· 2 shared

Activity by Year

2020-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 43 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

3 shared papersCancer Biology

J. Lee

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Dynamic phosphatase-recruitment controls B-cell selection and oncogenic signaling

J. Lee, M. E. Robinson, R. Sun, K. Kume, N. Ma, K. N. Cosgun, L. N. Chan, E. Leveille, H. Geng, V. S. Vykunta, B. R. Shy, A. Marson, S. G. Katz, J. Chen, E. Paietta, , M. Mueschen

This study identifies CD25 as a scaffold for phosphatases that regulate B-cell signaling and oncogenic processes, with opposing effects on B-cell malignancies and autoimmunity.

bioRxiv · Mar 13, 2023 · PreprintImmunology

Targeted engagement of β-catenin-Ikaros complexes in refractory B-cell malignancies

K. N. Cosgun, H. Jumaa, M. E. Robinson, X. Liang, G. Xiao, L. N. Chan, J. Lee, K. Kume, E. Leveille, D. Fonseca-Arce, D. Khanduja, H. L. Ng, N. Feldhahn, J. Song, W. C. Chan, , M. Mueschen

This study identifies a unique vulnerability in B-cell malignancies where GSK3β inhibitors disrupt β-catenin-Ikaros complexes, leading to MYC repression and cell death.

bioRxiv · Mar 13, 2023 · PreprintCancer Biology

Lgr5-mediated restraint of β-catenin is essential for B-lymphopoiesis and leukemia-initiation

K. N. Cosgun, M. E. Robinson, G. Deb, X. Yang, G. Xiao, T. Sadras, J. Lee, L. N. Chan, K. Kume, J. Winchester, Z. Chen, L. Yang, M. Mueschen

This study identifies Lgr5's role in restraining β-catenin to support B-lymphopoiesis and shows its therapeutic potential in B-ALL by targeting β-catenin hyperactivation.

bioRxiv · Mar 12, 2020 · PreprintCancer Biology