K. Kume

Beacon-based sleep status and physical activity monitoring in humans.

This study develops a method using a beacon accelerometer and smartphone to measure sleep and physical activity, achieving high precision in sleep classification and strong correlation with MET values for exercise intensity.

Dynamic phosphatase-recruitment controls B-cell selection and oncogenic signaling

This study identifies CD25 as a scaffold for phosphatases that regulate B-cell signaling and oncogenic processes, with opposing effects on B-cell malignancies and autoimmunity.

Targeted engagement of β-catenin-Ikaros complexes in refractory B-cell malignancies

This study identifies a unique vulnerability in B-cell malignancies where GSK3β inhibitors disrupt β-catenin-Ikaros complexes, leading to MYC repression and cell death.

Functionally conserved Pkd2, mutated in autosomal dominant polycystic kidney disease, localizes to the endoplasmic reticulum and regulates cytoplasmic calcium homeostasis in fission yeast

This study shows that Pkd2, a homolog of human polycystin-2, localizes to the ER and regulates calcium homeostasis in fission yeast, with functional conservation between species.

The regulation of circadian rhythm by insulin signaling in Drosophila

This study shows insulin signaling regulates circadian rhythm in Drosophila by altering period length and amplitude, with dilp5 as a key ligand.

Phylogenomics invokes the clade housing Cryptista, Archaeplastida, and Microheliella maris.

This study clarifies the phylogenetic position of Microheliella maris, placing it as a basal lineage of Cryptista and proposing a new clade Pancryptista, which includes Archaeplastida and M. maris.

Lgr5-mediated restraint of β-catenin is essential for B-lymphopoiesis and leukemia-initiation

This study identifies Lgr5's role in restraining β-catenin to support B-lymphopoiesis and shows its therapeutic potential in B-ALL by targeting β-catenin hyperactivation.

Signaling input from divergent pathways subverts malignant B-cell transformation

This study shows that malignant B-cell transformation requires convergence on a single oncogenic pathway, while divergent pathways can subvert transformation and are targets for new therapeutic strategies.

Barthelonids represent a deep-branching Metamonad clade with mitochondrion-related organelles generating no ATP.

This study determines the phylogenetic position of barthelonids and reveals their mitochondrion-related organelles lack ATP-generating capacity.