Author

H. Pai

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Plant Biology· 6

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Organism:plant (other)· 5 Research Focus:host-pathogen & immune response· 3 Research Focus:cell signaling & trafficking· 2 Research Focus:chromatin & epigenetic regulation· 2 Research Focus:cell type annotation· 1 Assay:cryo-EM· 1 Assay:DNA methylation· 1

Frequent Co-Authors

S. Kamoun· 6 shared C.-H. Wu· 4 shared J. Kourelis· 4 shared M. P. Contreras· 4 shared A. Maqbool· 3 shared A. Toghani· 3 shared E. L. H. Yuen· 3 shared H. Adachi· 3 shared

Activity by Year

2020-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 42 mutual co-author links

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6 shared papersPlant Biology

S. Kamoun

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6 papers

Recent·Most cited

Activation of plant immunity through conversion of a helper NLR homodimer into a resistosome

M. Selvaraj, A. Toghani, H. Pai, Y. Sugihara, J. Kourelis, E. L. H. Yuen, T. Ibrahim, H. Zhao, R. Xie, A. Maqbool, J. C. De la Concepcion, M. J. Banfield, L. Derevnina, B. Petre, D. M. Lawson, , M. P. Contreras

This study shows how the helper NLR NRC2 converts from a homodimer to a higher-order oligomer upon activation by the sensor NLR Rx, revealing the molecular mechanism of plant immune activation.

bioRxiv · Dec 17, 2023Plant Biology

A root-specific NLR network confers resistance to plant parasitic nematodes

D. Luedke, T. Sakai, J. Kourelis, A. Toghani, H. Adachi, A. Posbeyikian, R. Frijters, H. Pai, A. Harant, K. Ernst, M. Ganal, A. Verhage, C.-H. Wu, S. Kamoun

The paper identifies a root-specific NLR gene cluster in tomato that confers resistance to nematodes and evolved from an ancient NRC network.

bioRxiv · Dec 14, 2023 · PreprintPlant Biology

The nucleotide binding domain of NRC-dependent disease resistance proteins is sufficient to activate downstream helper NLR oligomerization and immune signaling

M. P. Contreras, H. Pai, R. Thompson, J. Claeys, H. Adachi, S. Kamoun

bioRxiv · Nov 30, 2023Plant Biology

Resurrection of plant disease resistance proteins via helper NLR bioengineering

M. P. Contreras, H. Pai, M. Selvaraj, A. Toghani, D. M. Lawson, Y. Tumtas, C. Duggan, E. L. H. Yuen, C. E. M. Stevenson, A. Harant, A. Maqbool, C.-H. Wu, T. O. Bozkurt, S. Kamoun, L. Derevnina

A helper NLR is mutated to evade inhibition by a parasite effector, restoring disease resistance gene activity.

bioRxiv · Dec 11, 2022Plant Biology

Sensor NLR immune proteins activate oligomerization of their NRC helper

M. P. Contreras, H. Pai, Y. Tumtas, C. Duggan, E. L. H. Yuen, A. Vergara Cruces, J. Kourelis, H.-K. Ahn, C.-H. Wu, T. O. Bozkurt, L. Derevnina, S. Kamoun

The paper shows that activation of plant NLRs Rx and Bs2 leads to oligomerization of the helper NLR NRC2, suggesting a distinct activation model compared to mammalian paired NLRs.

bioRxiv · Apr 25, 2022 · PreprintPlant Biology

Jurassic NLR: conserved and dynamic evolutionary features of the atypically ancient immune receptor ZAR1

H. Adachi, T. Sakai, J. Kourelis, H. Pai, J. L. Gonzalez Hernandez, A. Maqbool, S. Kamoun

This study reconstructs the evolutionary history of the ancient ZAR1 NLR immune receptor, revealing conserved features and novel domain acquisitions across plant lineages.

bioRxiv · Oct 12, 2020Plant Biology