H. Sano

The polyol pathway is an evolutionarily conserved system for sensing glucose uptake

The paper shows the polyol pathway senses glucose uptake in flies and mice, enabling metabolic remodeling through ChREBP/MondoA activation.

The polyol pathway is a crucial glucose sensor in Drosophila

This study identifies the polyol pathway as a glucose sensor in Drosophila that activates the metabolic regulator Mondo, linking glucose levels to transcriptional responses.