H. Aoki

LAG-3 blockade reactivates the CD8+ T cell expansion program to re-expand contracted clones in the tumor

This study identifies a transcriptomic signature predicting CD8+ T cell clone expansion rates and shows LAG-3 blockade reactivates this signature to re-expand contracted clones in tumors.

A mechanism of melanogenesis mediated by E-cadherin downregulation and its involvement in solar lentigines

This study identifies E-cadherin downregulation as a mechanism driving melanogenesis in age spots and shows that Rosa multiflora extract can upregulate E-cadherin in keratinocytes.

CD8+ T-cell memory induced by successive SARS-CoV-2 mRNA vaccinations is characterized by clonal replacement

The paper tracks CD8+ T-cell clonotypes after three SARS-CoV-2 mRNA vaccinations and finds that clonotypes from earlier shots are replaced by new ones after subsequent boosters.

Clonal spreading of tumor-infiltrating T cells underlies the robust antitumor immune responses

This study shows that polyclonal expansion of tumor-reactive T cells, not oligoclonal expansion, correlates with antitumor effects in response to anti-PD-L1 and anti-CD4 treatments.

Development of a Method Combining Peptidiscs and Proteomics to Identify, Stabilize and Purify a Detergent-Sensitive Membrane Protein Assembly

The paper develops a method using peptidiscs and proteomics to stabilize and identify detergent-sensitive membrane protein complexes, demonstrating its effectiveness with the E. coli Sec system.

The polyol pathway is an evolutionarily conserved system for sensing glucose uptake

The paper shows the polyol pathway senses glucose uptake in flies and mice, enabling metabolic remodeling through ChREBP/MondoA activation.

T cell receptor (TCR) repertoire analysis reveals a highly conserved TCR repertoire in a bilateral tumor mouse model

This study shows that the TCR repertoire is highly conserved between bilateral tumors in a mouse model, supporting its use for temporal analysis of antitumor T cell responses.