A simple strategy to reduce the salivary gland and kidney uptake of PSMA targeting small molecule radiopharmaceuticals
T. M. Kalidindi, S. G. Lee, K. Jou, G. Chakraborty, M. Skafida, S. T. Tagawa, N. H. Bander, H. Schoder, L. Bodei, N. Pandit-Taskar, J. S. Lewis, S. M. Larson, J. R. Osborne, N. Pillarsetty
This study shows adding cold PSMA-11 reduces salivary gland and kidney uptake of [177Lu]-PSMA-617 without affecting tumor uptake in mice.
bioRxiv · Jul 24, 2020Pharmacology & Toxicology