Transient genomic instability drives tumorigenesis through accelerated clonal evolution
O. Shoshani, B. Bakker, Y. Wang, D. H. Kim, M. Maldonado, M. A. Demarest, J. Artates, O. Zhengyu, A. Mark, R. Wardenaar, R. Sasik, D. C. Spierings, B. Vitre, K. Fisch, F. Foijer, D. W. Cleveland
This study compares chronic and transient chromosomal instability in mice, showing that transient instability accelerates tumor formation through rapid clonal evolution.
bioRxiv · Nov 17, 2020Cancer Biology