Author

R. Vaughan

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 1 Evolutionary Biology· 1 Pharmacology & Toxicology· 1 Physiology· 1

Signature Assays, Organisms & Methods

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Organism:human· 3 Approach:experimental assay· 2 Research Focus:gene regulatory network inference· 2 Approach:statistical model· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:differential expression· 1

Frequent Co-Authors

C. S. Jiang· 2 shared A. D. Auerbach· 1 shared A. Di Lorenzo· 1 shared A. G. Wibmer· 1 shared A. Goldfarb· 1 shared A. Koren· 1 shared A. L. H. Webster· 1 shared A. Mark· 1 shared

Activity by Year

2019-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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2 shared papersEvolutionary Biology

C. S. Jiang

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Author profile →

4 papers

Recent·Most cited

Sex differences in inter-individual gene expression variability across human tissues

S. Khodursky, C. S. Jiang, E. B. Zheng, R. Vaughan, D. R. Schrider, L. Zhao

The paper identifies sex-differentially variable genes across human tissues and links them to biological functions and disease, suggesting a genetic basis and evolutionary model for sex-specific expression variability.

bioRxiv · Aug 9, 2022Evolutionary Biology

Fanconi Anemia Pathway Deficiency Drives Copy Number Variation in Squamous Cell Carcinomas

A. L. H. Webster, M. A. Sanders, K. Patel, R. Dietrich, R. J. Noonan, F. P. Lach, R. R. White, A. Goldfarb, K. Hadi, M. M. Edwards, F. X. Donovan, M. Jung, S. Sridhar, O. Fedrigo, H. Tian, , P. Campbell

This paper shows that FA pathway deficiency in squamous cell carcinomas leads to high structural variant rates and copy number alterations, linking genomic instability to tumor progression.

bioRxiv · Aug 14, 2021 · PreprintCancer Biology

Brown Adipose Tissue is Associated with Improved Cardiometabolic Health and Regulates Blood Pressure

T. Becher, S. Palanisamy, D. J. Kramer, S. J. Marx, A. G. Wibmer, I. Del Gaudio, S. D. Butler, C. S. Jiang, R. Vaughan, H. Schoder, A. Di Lorenzo, A. Mark, P. Cohen

This study links brown adipose tissue (BAT) to improved cardiometabolic health and blood pressure regulation in humans.

bioRxiv · Feb 8, 2020 · PreprintPhysiology

Novel Pure αVβ3 Integrin Antagonists That Do Not Induce Receptor Extension, Prime the Receptor, or Enhance Angiogenesis at Low Concentrations

J. Li, Y. Fukase, Y. Shang, W. Zou, J. Munoz-Felix, L. Buitrago, J. van Agthoven, Y. Zhang, R. Hara, Y. Tanaka, R. Okamoto, T. Yasui, T. Nakahata, T. Imaeda, K. Aso, , B. S. Coller

This paper designs and evaluates two small-molecule Vβ3 antagonists that inhibit cell adhesion and bone resorption without inducing receptor conformational changes or enhancing angiogenesis at low concentrations.

bioRxiv · May 24, 2019Pharmacology & Toxicology