H. T. Ong

This paper introduces a pipeline for 3D organoid analysis using multilevel segmentation and cellular topology to quantify morphology and topology changes under various stress conditions.

The paper identifies actin polymerization regulators that drive chiral actin swirling and left-right asymmetry in single cells and cell collectives.

The paper introduces a high-content 3D imaging platform for organoid development analysis, enabling automated, high-throughput imaging and AI-based quantification of morphological features across multiple scales.

The paper investigates the mechanical role of vinculin/β-catenin interaction in adherens junctions, showing that vinculin forms a direct structural connection with β-catenin to support mechanical tension and stabilize complexes.

The paper develops a single-cell assay to analyze EphA receptor clustering in cancer cells, revealing its persistence through division and association with migration and drug resistance.

This study investigates how forces affect filopodia adhesion, showing that myosin IIA and formins are essential for force-dependent adhesion and substrate preference.