S. Chia

Multiplexed Digital Characterisation of Misfolded Protein Oligomers via Solid-State Nanopores

This paper introduces a single-molecule method using solid-state nanopores and DNA barcoding to detect and characterize misfolded protein oligomers, demonstrating its application to α-synuclein in Parkinson's disease.

Maturation-dependent changes in the structure and seeding capacity of Aβ42 amyloid fibrils

This study investigates how Aβ42 amyloid fibrils change over time, showing increased length, thickness, and cross-β sheet content, which affects their ability to seed new aggregates.

Structure-based discovery of small molecule inhibitors of the autocatalytic proliferation of alpha-synuclein aggregates

This study identifies small molecules that inhibit alpha-synuclein aggregate proliferation using structure-based and kinetic assays.

Enhanced surface nano-analytics of transient biomolecular processes

This paper develops a lab-on-a-chip method for analyzing biomolecular processes with high sensitivity and single molecule resolution in physiological conditions.

Discovery of Potent Inhibitors of α-Synuclein Aggregation Using Structure-Based Iterative Learning

This paper uses structure-based machine learning to identify potent small molecule inhibitors of α-synuclein aggregation, achieving compounds two orders of magnitude more potent than previous reports.

Vitamin A and vitamin E metabolites comodulate amyloid-β aggregation

This study identifies retinoic acid and tocopherol as vitamin metabolites that modulate amyloid-β aggregation in vitro and in a C. elegans model, with combined effects that may cancel each other.

Infrared Nanospectroscopy Reveals the Molecular Interaction Fingerprint of an Aggregation Inhibitor with Single Aβ42 Oligomers

This study uses infrared nanospectroscopy to directly measure how bexarotene interacts with Aβ42 oligomers and fibrils, revealing a single hydrogen bond between the compound's carbonyl group and the aggregates.

Single-cell analysis of EphA clustering phenotypes to probe cancer cell heterogeneity

The paper develops a single-cell assay to analyze EphA receptor clustering in cancer cells, revealing its persistence through division and association with migration and drug resistance.