De novo Design of Peptides that Bind Specific Conformers of α-Synuclein
H. Wallace, H. Yang, S. K. Tan, H. Pan, R. Yang, J. Xu, H. Jo, C. Condello, N. Polizzi, W. DeGrado
This paper introduces a computational method to design peptides that bind specific conformers of α-synuclein fibrils, resulting in a peptide that slows amyloid formation and shows high specificity.
bioRxiv · Nov 14, 2023 · PreprintBiophysics