Author

N. Polizzi

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 2

Signature Assays, Organisms & Methods

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Approach:deep learning· 2 Research Focus:drug response / drug discovery· 1 Research Focus:protein design· 1 Assay:protein structure· 1 Assay:proteomics· 1 Approach:statistical model· 1

Frequent Co-Authors

H. Jo· 2 shared H. Yang· 2 shared W. DeGrado· 2 shared A. Ashworth· 1 shared C. Condello· 1 shared D. Gazgalis· 1 shared H. Pan· 1 shared H. Wallace· 1 shared

Activity by Year

2023-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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2 shared papersBiophysics

H. Jo

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2 papers

Recent·Most cited

De novo design of drug-binding proteins with predictable binding energy and specificity

L. Lu, X. Gou, S. Tan, S. Mann, H. Yang, X. Zhong, D. Gazgalis, J. Valdiviezo, H. Jo, Y. Wu, M. Diolaiti, A. Ashworth, N. Polizzi, W. DeGrado

This paper designs drug-binding proteins with low nanomolar affinity and predictable specificity using computational methods, validated by experimental measurements and structural analysis.

bioRxiv · Dec 23, 2023 · PreprintBiophysics

De novo Design of Peptides that Bind Specific Conformers of α-Synuclein

H. Wallace, H. Yang, S. K. Tan, H. Pan, R. Yang, J. Xu, H. Jo, C. Condello, N. Polizzi, W. DeGrado

This paper introduces a computational method to design peptides that bind specific conformers of α-synuclein fibrils, resulting in a peptide that slows amyloid formation and shows high specificity.

bioRxiv · Nov 14, 2023 · PreprintBiophysics