H. Jo

Synthesis and Biological Assessment of Chalcone and Pyrazoline Derivatives as novel inhibitor for ELF3-MED23 Interaction

This study synthesizes and evaluates chalcone and pyrazoline derivatives as ELF3-MED23 PPI inhibitors, showing compound 10 effectively reduces HER2 levels and induces apoptosis in HER2-positive gastric cancer cells.

De novo design of drug-binding proteins with predictable binding energy and specificity

This paper designs drug-binding proteins with low nanomolar affinity and predictable specificity using computational methods, validated by experimental measurements and structural analysis.

De novo Design of Peptides that Bind Specific Conformers of α-Synuclein

This paper introduces a computational method to design peptides that bind specific conformers of α-synuclein fibrils, resulting in a peptide that slows amyloid formation and shows high specificity.

Low oscillatory shear stress regulates Weibel-Palade body size and vWF release.

The paper shows that low oscillatory shear stress increases Weibel-Palade body size, enhancing vWF release and thrombotic potential in endothelial cells.

Designed Transmembrane Proteins Inhibit the Erythropoietin Receptor in a Custom Binding Topology

The paper designs transmembrane proteins that inhibit the erythropoietin receptor by competing with homodimerization in a custom binding topology.

A host defense peptide mimetic, brilacidin, potentiates caspofungin antifungal activity against human pathogenic fungi

This study identifies brilacidin as a compound that enhances the antifungal activity of caspofungin against multiple human pathogenic fungi, including overcoming resistance mechanisms.

Response to immune checkpoint blockade improved in pre-clinical model of breast cancer after bariatric surgery

This study shows that bariatric surgery followed by immune checkpoint blockade improves breast cancer outcomes in formerly obese mice, despite weight loss being less effective than diet in reducing tumor burden.

Aging-regulated TUG1 is dispensable for endothelial cell function

This study shows that TUG1, despite high expression and conservation, does not significantly affect endothelial cell function in vitro.

Stable Flow-induced Expression of KLK10 Inhibits Endothelial Inflammation and Atherosclerosis

This study identifies KLK10 as a flow-sensitive endothelial protein that inhibits inflammation and atherosclerosis through a PAR1/2-dependent mechanism involving HTRA1 regulation.

Brilacidin, a COVID-19 Drug Candidate, demonstrates broad-spectrum antiviral activity against human coronaviruses OC43, 229E and NL63 through targeting both the virus and the host cell

This study shows brilacidin has broad-spectrum antiviral activity against multiple human coronaviruses by targeting both the virus and host cell heparan sulfate proteoglycans.

Systematic analysis of SARS-CoV-2 infection of an ACE2-negative human airway cell

This study identifies H522 cells as ACE2-negative human cells permissive to SARS-CoV-2 infection, revealing alternative receptor usage and host response mechanisms.

Data-driven multiplexed microtomography of endogenous subcellular dynamics

This paper introduces a data-driven method for multiplexed microtomography using refractive index imaging to study endogenous subcellular dynamics without exogenous labels.

Endothelial reprogramming by disturbed flow revealed by single-cell RNA and chromatin accessibility study

The paper uses single-cell RNA and chromatin accessibility data to show disturbed flow reprograms endothelial cells from atheroprotective to pro-atherogenic phenotypes.