BiophysicsbioRxiv
Constitutive activity of ionotropic glutamate receptors via hydrophobic substitutions in the ligand-binding domain
S. Seljeset, O. Sintsova, Y. Wang…·T. Lynagh
The paper identifies a conserved aspartate residue in NMDA receptors that controls ligand potency and activity, showing substitutions can bypass ligand binding and reveal evolutionary adaptations in a homomeric iGluR.
DOI 10.1016/j.str.2024.04.001