Author

T. Lynagh

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 3 Biochemistry· 1 Evolutionary Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Assay:electrophysiology· 3 Research Focus:cell signaling & trafficking· 2 Research Focus:chromatin & epigenetic regulation· 2 Organism:human· 2 Organism:mouse· 2 Organism:rat· 2 Approach:comparative / phylogenetic analysis· 1

Frequent Co-Authors

A. Borve· 1 shared A. Hejnol· 1 shared C. B. Borg· 1 shared C. Lund· 1 shared D. Weis· 1 shared E. P. Bennett· 1 shared H. Hausen· 1 shared H. Y. Harb· 1 shared

Activity by Year

2020-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 16 mutual co-author links

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1 shared paperEvolutionary Biology

A. Borve

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Author profile →

5 papers

Recent·Most cited

Constitutive activity of ionotropic glutamate receptors via hydrophobic substitutions in the ligand-binding domain

S. Seljeset, O. Sintsova, Y. Wang, H. Y. Harb, T. Lynagh

The paper identifies a conserved aspartate residue in NMDA receptors that controls ligand potency and activity, showing substitutions can bypass ligand binding and reveal evolutionary adaptations in a homomeric iGluR.

bioRxiv · Aug 3, 2023Biophysics

Comparative analysis defines a broader FMRFamide-gated sodium channel family and determinants of neuropeptide sensitivity

M. Dandamudi, H. Hausen, T. Lynagh

The paper identifies amino acid residues determining FMRFamide activity at FaNaC channels and shows evolutionary conservation of ligand recognition determinants across DEG/ENaC channels.

bioRxiv · Mar 23, 2022Biochemistry

Peripheral and central employment of acid-sensing ion channels during early bilaterian evolution

J. Marti-Solans, A. Borve, P. Bump, A. Hejnol, T. Lynagh

The paper investigates the evolutionary emergence and functional role of acid-sensing ion channels (ASICs) in bilaterian animals, finding they originated as a bilaterian innovation and were initially expressed peripherally before being incorporated into the brain.

bioRxiv · Mar 17, 2022Evolutionary Biology

The M1 and pre-M1 segments contribute differently to ion selectivity in ASICs and ENaCs

Z. P. Sheikh, M. Wulf, S. Friis, M. Althaus, T. Lynagh, S. A. Pless

This study shows that the pre-M1 and M1 regions of ASICs and ENaCs differentially contribute to ion selectivity through structural and functional analyses.

bioRxiv · Feb 16, 2021Biophysics

Mechanism and site of action of big dynorphin on ASIC1a

C. B. Borg, N. Braun, S. A. Heusser, Y. Bay, D. Weis, I. Galleano, C. Lund, W. Tian, L. M. Haugaard-Kedstroem, E. P. Bennett, T. Lynagh, K. Stromgaard, J. Andersen, S. Pless

This study identifies the binding site and mechanism of big dynorphin on ASIC1a, revealing the acidic pocket as the interaction site and highlighting its potential for therapeutic development.

Proceedings of the National Academy of Sciences · Mar 12, 2020Peer-reviewedBiophysics