H.-E. Kim

Unveiling the Intercompartmental Signaling Axis: Mitochondrial to ER Stress Response (MERSR) and its Impact on Proteostasis

The paper identifies a Mitochondria to ER Stress Response (MERSR) that enhances proteostasis by modulating UPRER and PERK-eIF2 signaling in disease models.

The UPRmt Preserves Mitochondrial Import to Extend Lifespan

This study shows that activating the UPRmt through ATFS-1 increases mitochondrial import efficiency, preserves import capacity with age, and extends lifespan in worms.