A. Dillin

CRISPR screens and lectin microarrays identify novel high mannose N-glycan regulators

The paper uses CRISPR screens and lectin microarrays to identify TM9SF3 and the CCC complex as novel regulators of high mannose N-glycan synthesis.

The microenvironment dictates glycocalyx construction and immune surveillance

This study shows that the physical properties of the microenvironment influence glycocalyx composition and immune surveillance in vitro using physiologically relevant models.

Lipid homeostasis is essential for a maximal ER stress response

This study identifies let-767 as a gene critical for lipid and ER protein homeostasis, showing that lipid metabolism influences the ER stress response.

Aging alters the metabolic flux signature of the ER unfolded protein response in vivo in mice

This study shows that aging in mice leads to an exaggerated and less effective endoplasmic reticulum unfolded protein response (UPRER) under stress, with altered metabolic flux patterns in protein synthesis and lipid production.

Metabolic flux signatures of the ER unfolded protein response in vivo reveal decreased hepatic de novo lipogenesis and mobilization of lipids from adipose tissue to liver

This study uses metabolic labeling and mass spectrometry to analyze UPRER-induced metabolic changes in mouse liver, revealing reduced de novo lipogenesis and lipid mobilization from adipose to liver.

Measuring expression heterogeneity of single-cell cytoskeletal protein complexes

The paper introduces a method to measure single-cell cytoskeletal protein complex expression heterogeneity and finds some cells upregulate other cytoskeletal complexes in response to stress.

The UPRmt Preserves Mitochondrial Import to Extend Lifespan

This study shows that activating the UPRmt through ATFS-1 increases mitochondrial import efficiency, preserves import capacity with age, and extends lifespan in worms.

Adhesion-mediated mechanosignaling forces mitohormesis

The paper shows that adhesion-mediated mechanosignaling activates a mitochondrial stress response through SLC9A1 and HSF1, altering mitochondrial function in aging and cancer.

Transient activation of the UPRER is an essential step in the acquisition of pluripotency during reprogramming

This study shows that transient activation of the UPRER is essential for successful reprogramming of somatic cells into pluripotency and can predict reprogramming efficiency.

A non-canonical arm of UPRER mediates longevity through ER remodeling and lipophagy.

This study identifies a non-canonical UPRER pathway that extends lifespan through ER remodeling and lipophagy, independent of chaperone function.