Hyperpolyploidization of hepatocyte initiates preneoplastic lesion formation in the liver
H.-W. Chao, H. Lin, Y.-S. Huang, J.-M. Fustin, M. Doi, H. Chen, H.-H. Lai, S.-H. Lin, Y.-L. Lee, P.-C. King, H.-S. Hou, H.-W. Chen, P.-Y. Young
This study shows that hyperpolyploidization of hepatocytes in the centrilobular region initiates preneoplastic lesion formation, with AURKB upregulation and phosphorylation driving this process in HCC development.
bioRxiv · Aug 23, 2020Pathology