PathologybioRxiv
Hyperpolyploidization of hepatocyte initiates preneoplastic lesion formation in the liver
H.-W. Chao, H. Lin, Y.-S. Huang…·P.-Y. Young
This study shows that hyperpolyploidization of hepatocytes in the centrilobular region initiates preneoplastic lesion formation, with AURKB upregulation and phosphorylation driving this process in HCC development.
DOI 10.1038/s41467-020-20572-8