Cancer BiologybioRxiv
Hydrogen Sulfide Coordinates Glucose Metabolism Switch through Destabilizing Tetrameric Pyruvate Kinase M2
R.-H. Wang, P.-R. Chen, Y.-T. Chen…·K.-T. Lin
This study shows hydrogen sulfide destabilizes PKM2 tetramer through sulfhydration at cysteine 326, rewiring glucose metabolism and inhibiting tumor growth.
DOI 10.1038/s41467-024-51875-9