Author

H.-L. Ou

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Cancer Biology· 2

Signature Assays, Organisms & Methods

Click to filter · or open tag

Organism:mouse· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1

Frequent Co-Authors

D. Macias· 2 shared D. Munoz-Espin· 2 shared E. Gonzalez-Gualda· 2 shared A. B. Popov· 1 shared A. G. Baker· 1 shared A. Vernet· 1 shared C. Martins· 1 shared C. Sanghera· 1 shared

Activity by Year

2022-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

2 shared papersCancer Biology

D. Macias

Mutual co-authors in cluster

Author profile →

2 papers

Recent·Most cited

In Vivo Monitoring of Cellular Senescence by Photoacoustic and Fluorescence Imaging Utilizing a Nanostructured Organic Probe

A. G. Baker, H.-L. Ou, M. Hartono, A. B. Popov, E. L. Brown, J. Joseph, M. Golinska, C. Sanghera, E. Gonzalez-Gualda, D. Macias, T. R. Else, H. F. Greer, A. Vernet, S. E. Bohndiek, L. Fruk, D. Munoz-Espin

This study develops a nanostructured organic probe, NanoJaggs, for in vivo monitoring of cellular senescence using photoacoustic and fluorescence imaging, showing specificity for chemotherapy-induced senescence in tumors.

bioRxiv · Jul 12, 2023 · PreprintCancer Biology

A tumour-promoting senescent secretome triggered by platinum chemotherapy exploits a targetable TGFβR1/Akt-mTOR axis in lung cancer

E. Gonzalez-Gualda, D. Macias, S. Morsli, E. Martin, H.-L. Ou, M. Denholm, I. Olan, R. Hoffmann, M. Dane, D. Veroutis, G. Medrano, F. Mulero, C. Martins, M. Barbacid, V. Gorgoulis, , D. Munoz-Espin

This study shows platinum chemotherapy induces a senescent secretome in lung cancer that promotes tumor growth via the TGFβR1/Akt-mTOR axis, and targeting this pathway reduces tumor burden.

bioRxiv · Aug 1, 2022 · PreprintCancer Biology