Author

I. Olan

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 1 Cancer Biology· 1 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 2 Assay:proteomics· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:drug response / drug discovery· 1 Approach:machine learning (classical)· 1

Frequent Co-Authors

M. Narita· 2 shared A. Garcia-Gimenez· 1 shared A. Godsinia· 1 shared A. R. Fard· 1 shared B. Huntly· 1 shared C. Kapeni· 1 shared C. M. Sauer· 1 shared C. Martins· 1 shared

Activity by Year

2021-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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2 shared papersCancer Biology

M. Narita

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

LGR5 targeting molecules as therapeutic agents for multiple cancer types

H.-C. Chen, N. Mueller, K. Stott, E. Rivers, C. Kapeni, C. M. Sauer, F. Beke, S. Walsh, N. Ashman, L. M. O'Brien, A. R. Fard, A. Godsinia, F. Joud, O. Giger, I. Zlobec, , M. de la Roche

This study develops LGR5-targeting antibodies and therapeutics that effectively kill CRC, HCC, and pre-B ALL cancer cells while sparing normal tissues.

bioRxiv · Sep 1, 2022 · PreprintCell Biology

A tumour-promoting senescent secretome triggered by platinum chemotherapy exploits a targetable TGFβR1/Akt-mTOR axis in lung cancer

E. Gonzalez-Gualda, D. Macias, S. Morsli, E. Martin, H.-L. Ou, M. Denholm, I. Olan, R. Hoffmann, M. Dane, D. Veroutis, G. Medrano, F. Mulero, C. Martins, M. Barbacid, V. Gorgoulis, , D. Munoz-Espin

This study shows platinum chemotherapy induces a senescent secretome in lung cancer that promotes tumor growth via the TGFβR1/Akt-mTOR axis, and targeting this pathway reduces tumor burden.

bioRxiv · Aug 1, 2022 · PreprintCancer Biology

The chromatin regulator HMGA1a undergoes phase separation in the nucleus

H. Zhu, M. Narita, J. A. Joseph, G. Krainer, W. E. Arter, I. Olan, K. L. Saar, N. Ermann, J. R. Espinosa, Y. Shen, M. A. Kuri, R. Qi, T. J. Welsh, Y. Xu, R. Collepardo-Guevara, , T. Knowles

This study shows HMGA1a undergoes phase separation in the nucleus, driven by protein-DNA interactions and its disordered C-terminal tail.

bioRxiv · Oct 14, 2021Biophysics