BiophysicsbioRxiv
Phosphorylation modulates estrogen receptor disorder by altering long-range hydrophobic interactions
Z. Du, H. Wang, C. Wu…·S. Yang
This study shows phosphorylation at Ser118 of the estrogen receptor's disordered N-terminal domain alters long-range hydrophobic interactions, leading to conformational changes that activate transcriptional function.
DOI 10.1038/s41586-024-08400-1