Z. Du

Global invasion history and genomic signatures of adaptation of a highly invasive lace bug

This study investigates the genomic basis of invasion in the sycamore lace bug, identifying adaptation signatures and invasion routes through genomic analysis.

Effects of fructooligosaccharides and Saccharomyces boulardii on the compositional structure and metabolism of gut microbiota in students

This study examines how fructooligosaccharides and Saccharomyces boulardii affect gut microbiota structure and metabolism in students using an in vitro model, finding that their combination has unique benefits.

An improved epigenetic counter to track mitotic age in normal and precancerous tissues

This paper develops and validates stemTOC, a DNA methylation-based counter for mitotic age, showing its utility in normal and precancerous tissues for cancer risk prediction.

Extracting herbicide and antibiotic natural products from a plant-microbe interaction system

This study identifies a plant-microbe interaction system where a rhizosphere bacterium produces molecules with dual antibiotic and herbicide functions, offering insights into novel natural product discovery.

Phosphorylation modulates estrogen receptor disorder by altering long-range hydrophobic interactions

This study shows phosphorylation at Ser118 of the estrogen receptor's disordered N-terminal domain alters long-range hydrophobic interactions, leading to conformational changes that activate transcriptional function.

Vacuolar H+-ATPase Determines Daughter Cell Fates through Asymmetric Segregation of the Nucleosome Remodeling and Deacetylase Complex

The paper shows that V-ATPase asymmetrically segregates the NuRD complex during cell division, influencing daughter cell survival or apoptosis through pH differences.

Histone lactylation antagonizes senescence and skeletal muscle aging via facilitating gene expression reprogramming

This study shows histone lactylation counteracts senescence and skeletal muscle aging by reprogramming gene expression, with exercise enhancing lactylation and improving muscle function.

In vivo reprogramming of wound-resident cells generates skin with hair

This study reprograms wound-resident cells in adult mice to generate skin with hair follicles, demonstrating de novo appendage formation.

P bodies coat germ granules to promote transgenerational gene silencing in C. elegans

This study shows P body factors coat germ granules in C. elegans to enable transgenerational gene silencing by maintaining small RNA factors and secondary small RNA amplification.

Three-dose vaccination-induced immune responses protect against SARS-CoV-2 Omicron-BA.2

This study evaluates the effectiveness of three-dose SARS-CoV-2 vaccination against Omicron BA.2 breakthrough infections and finds that third-dose vaccination significantly reduces infection rates and severity.

Allele-specific activation, enzyme kinetics, and inhibitor sensitivities of EGFR exon 19 deletion mutations in lung cancer

The paper identifies allele-specific functional differences among EGFR exon 19 deletion variants, showing how sequence and structure motifs affect oncogenic activity, dimerization, and TKI sensitivity.

Nasal prevention of SARS-CoV-2 infection by intranasal influenza-based boost vaccination

This study shows that intranasal influenza-based boost vaccination enhances mucosal and systemic immunity against SARS-CoV-2, effectively preventing infection in both upper and lower respiratory systems.

Multi-Functionalized Self-Bonding MXene for Minimal-invasive Jet-injected Neural Interface and Tissue Healing

The paper develops a minimal-invasive neural interface using MXene nanosheets to promote nerve regeneration and electrophysiology recording in mice.

SARS-CoV-2 hijacks neutralizing dimeric IgA for enhanced nasal infection and injury

This study shows that dimeric IgA antibodies can enhance SARS-CoV-2 nasal infection and injury in Syrian hamsters by engaging CD209 as an alternative receptor.

OPAM, an Open source, 3D printed Low-cost Micro-Manipulator for Single Cell Manipulation

The paper introduces OPAM, a low-cost, 3D-printed micromanipulator for single cell manipulation, demonstrating its ability to capture and transfer single cells under a microscope.

The creation of functioning gastrojejunostomy following magnetic compression

This study evaluates methods for creating gastrojejunostomy using magnetic compression and pyloric ligation in rabbits, finding that pyloric ligation provides better long-term patency than paclitaxel-loaded magnets.

New insights into the earlier evolutionary history of epiphytic macrolichens

The paper identifies a Jurassic fossil as an epiphytic macrolichen, suggesting macrolichen diversity predates the Cenozoic diversification of extant lineages.

Revealing Atomic-scale Molecular Diffusion of a Plant Transcription Factor WRKY domain protein along DNA

This study uses molecular dynamics simulations to reveal atomic-scale diffusion dynamics of the WRKY transcription factor along DNA, including base-pair stepping and strand preference.

A Computational and Biochemical Study of -1 Ribosomal Frameshifting in Human mRNAs

The paper identifies putative -1 ribosomal frameshifting events in human mRNAs, confirming functional frameshifting in CDK5R2 and SEMA6C.

Structural characterization of cocktail-like targeting polysaccharides from Ecklonia kurome Okam and their anti-SARS-CoV-2 activities in vitro

This study identifies a mixture of polysaccharides from Ecklonia kurome that inhibit SARS-CoV-2 by targeting multiple viral proteins, with the cocktail-like effect enhancing antiviral activity.

In vivo lentiviral vector gene therapy to cure hereditary tyrosinemia type 1 and prevent development of precancerous and cancerous lesions

This study cures hereditary tyrosinemia type 1 in pigs using in vivo lentiviral gene therapy, preventing liver fibrosis and tumorigenic pathways.

A comparison of Remdesivir versus Au22Glutathione18 in COVID-19 golden hamsters: a better therapeutic outcome of gold compound

This study compares the therapeutic effects of Remdesivir and Au22Glutathione18 in COVID-19 golden hamsters, finding that the gold compound better suppresses viral replication and inflammation.

Porous upconversion nanostructures as bimodal biomedical imaging contrast agents

This study designs core-porous shell upconversion nanoparticles to enhance both fluorescent and MRI signals for dual-modal biomedical imaging.

Highly multiplexed immunofluorescence images and single-cell data of immune markers in tonsil and lung cancer

The paper describes a dataset of multiplexed immunofluorescence images and single-cell immune marker data from human tonsil and lung cancer tissues, along with analysis methods and tools.

Volumetric two-photon imaging in live cells and embryos via axially gradient excitation

This paper introduces a gradient two-photon microscopy technique that enables rapid volumetric imaging with reduced phototoxicity by using two axially gradient excitation beams.

Numerical simulation for behind armor blunt trauma of human torso under non-penetrating ballistic impact

This study simulates behind armor blunt trauma in a human torso model under ballistic impact to evaluate how buffer layers reduce injury severity.

Multilocus sequence analysis, a rapid and accurate identification tool for taxonomic classification, evolutionary relationship and population biology of the genus Shewanella.

This paper establishes a multilocus sequence analysis (MLSA) method using six protein-coding genes to classify Shewanella strains, revealing evolutionary relationships and population biology.

A metastable contact and structural disorder in the estrogen receptor transactivation domain

This study investigates the structure and function of the estrogen receptor alpha N-terminal domain using multiple techniques, revealing metastable contacts and their role in transactivation.

Risk Factors Associated with Dengue Virus Infection in Guangdong Province: a Community-based Case-control Study

This study identifies risk and protective factors for dengue virus infection in Guangdong Province through a case-control study, finding activities in the park, outdoor sports, and poor indoor daylight quality as risk factors, and air-condition use as protective.