W. R. Gordon

The paper identifies eight mutations that convert a hydroxynitrile lyase into an efficient esterase by correcting structural differences using shortest path maps.

The paper introduces RAD-TGTs, a method to measure cellular tensions using DNA duplexes that rupture under force, with readout via flow cytometry and DNA sequencing.

This study identifies a unique mechanism by which dystroglycan is cleaved by MMPs, showing that structural changes disrupt DGC integrity and contribute to disease.

This study investigates how dystrophin mutations affect focal adhesion tension and YAP-mediated mechanotransduction in myoblasts.

The paper investigates the molecular mechanism of ssDNA specificity by HUH-endonucleases and demonstrates how this can be engineered for multiplexed HUH-tagging and bioconjugation.

This paper describes the development of an affordable centrifuge force microscope (CFM) by students, emphasizing educational value and hands-on research experience.

This study investigates the mechanism of ssDNA binding by a viral HUH-endonuclease through alanine scanning of an electrostatic patch, revealing key residues critical for binding specificity and activity.

This paper develops a BRET-based molecular tension sensor with improved spectral properties and dynamic range compared to FRET-based sensors, demonstrating its application in studying tension gradients in focal adhesions.