Cell BiologybioRxivPreprint
UNC-45A Drives ATP-Independent Microtubule Destabilization via Defect Recognition and Repair Inhibition Contributing to Neurite Dystrophy
Asumi Hoshino, Brian T. Castle, Mihir Shetty…·Martina Bazzaro
This study identifies UNC-45A as an ATP-independent microtubule severing protein that inhibits repair of defects, leading to microtubule loss and neurite dystrophy in Alzheimer's disease.