Michael K. Lee

This study shows neurons inefficiently metabolize internalized α-synuclein fibrils, which become truncated and resist degradation, while glial cells rapidly degrade them.

This study identifies UNC-45A as an ATP-independent microtubule severing protein that inhibits repair of defects, leading to microtubule loss and neurite dystrophy in Alzheimer's disease.

This study identifies CK2 as a regulator of tauopathy by modulating tau phosphorylation, neuroinflammation, and synaptic dysfunction in mice.

This paper evaluates a prodrug of a glutathione surrogate in an Alzheimer's mouse model, showing it reduces oxidative stress, amyloid pathology, and neurodegeneration while identifying metabolic biomarkers.

This study shows that deleting Glyoxalase 1 worsens acetaminophen-induced liver damage in mice by increasing oxidative stress and necrosis.

The paper identifies UNC-45A expression in proliferative cells of the mouse genital tract and microtubule-rich areas of the nervous system, suggesting its potential role in ovarian cancer and neurodegeneration.

The paper shows that partial inhibition of mitochondrial complex I protects against neurodegeneration in Alzheimer's mice by improving energy homeostasis, synaptic function, and reducing inflammation.