Hong Zhou

scCircaSim generates circadian single-cell and spatial transcriptomic data with known ground truth to evaluate analysis methods.

This study maps organ-specific endothelial surface proteomes in vivo to identify tissue-selective vascular targets for therapy.

This study shows that fruitless (fru) is regulated by doublesex (dsx) in the gonad stem cell niche, promoting sexual dimorphism independently of Transformer-mediated alternative splicing.

The paper validates the principle of co-adaptation between tRNA gene copy number and amino acid usage across three life domains, showing it improves translation efficiency in both organisms and individual proteins.

This paper demonstrates semiconductor voltage nanosensors that self-insert into cell membranes and optically record membrane potential with single-particle sensitivity.