NeurosciencebioRxivPreprint
LINE-1 replication in a mouse TDP-43 model of neurodegeneration marks motor cortex neurons for cell-intrinsic and non-cell autonomous programmed cell death.
Shreevidya Korada, Oliver H. Tam, Hunter C. Greco…·Roger B. Sher
This study shows that TDP-43 pathology in mice triggers LINE-1 retrotransposon replication in motor cortex neurons and glia, leading to cell-intrinsic and non-cell autonomous programmed cell death.
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