Author

I. A. Shkel

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 4

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:chromatin & epigenetic regulation· 2 Organism:E. coli· 2 Research Focus:cell signaling & trafficking· 1 Assay:fluorescence / live-cell microscopy· 1 Approach:microscopy & imaging analysis· 1 Research Focus:protein folding & dynamics· 1 Assay:protein structure· 1

Frequent Co-Authors

X. Cheng· 3 shared E. Zytkiewicz· 2 shared M. T. Record· 2 shared T. Record· 2 shared A. Drennan· 1 shared A. G. Kozlov· 1 shared A. Rupanya· 1 shared B. Nguyen· 1 shared

Activity by Year

2020-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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3 shared papersBiochemistry

X. Cheng

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Author profile →

4 papers

Recent·Most cited

BiochemistrybioRxivPreprintJul 12, 2023

Quantifying Amide-Aromatic Interactions at Molecular and Atomic Levels: Experimentally-determined Enthalpic and Entropic Contributions to Interactions of Amide sp2O, N, C and sp3C Unified Atoms with Naphthalene sp2C Atoms in Water

E. Zytkiewicz, I. A. Shkel, X. Cheng…·T. Record

The paper quantifies enthalpic and entropic contributions of amide-aromatic interactions in water, revealing their thermodynamic driving forces and relevance to protein processes.

DOI 10.1101/2023.07.12.548600

statistical model

𝕏 PostBluesky

BiochemistrybioRxivJan 17, 2022

How Glutamate Promotes Liquid-liquid Phase Separation and DNA Binding Cooperativity of E. coli SSB Protein

A. G. Kozlov, X. Cheng, H. Zhang…·T. M. Lohman

This study shows that potassium glutamate promotes liquid-liquid phase separation and non-nearest-neighbor cooperativity of E. coli SSB protein through amide group interactions, while KCl inhibits these processes.

DOI 10.1016/j.jmb.2022.167562

E. coliprotein structure

𝕏 PostBluesky

BiochemistrybioRxivPreprintMay 26, 2020

Experimentally-Determined Strengths of Atom-Atom (C, N, O) Interactions Responsible for Protein Self-Assembly in Water: Applications to Folding and Other Protein Processes

X. Cheng, I. A. Shkel, K. O'Connor, T. Record

The paper quantifies intrinsic strengths of atom-atom interactions in amides relative to water, providing insights into their roles in protein self-assembly and stability.

DOI 10.1101/2020.05.26.104851

proteomicsexperimental assay

𝕏 PostBluesky

BiochemistrybioRxivFeb 4, 2020

Fluorescence-Detected Conformational Changes in Duplex DNA in Open Complex Formation by E. coli RNA Polymerase: Upstream Wrapping and Downstream Bending Precede Clamp Opening and Insertion of the Downstream Duplex

R. Sreenivasan, I. A. Shkel, M. Chhabra…·M. T. Record

This study uses FRET and PIFE to analyze DNA conformational changes during E. coli RNA polymerase open complex formation, revealing upstream wrapping and downstream bending before clamp opening.

DOI 10.1021/acs.biochem.0c00098

E. colifluorescence / live-cell microscopy

𝕏 PostBluesky