Author

I. Ahel

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 1 Cell Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell signaling & trafficking· 1 Approach:deep learning· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1 Research Focus:protein folding & dynamics· 1 Assay:protein structure· 1

Frequent Co-Authors

M. Schuller· 2 shared A. Ashworth· 1 shared A. R. Renslo· 1 shared B. K. Shoichet· 1 shared C. Chatrin· 1 shared D. Ahel· 1 shared D. Baretic· 1 shared D. FearoniD· 1 shared

Activity by Year

2022-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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2 shared papersCell Biology

M. Schuller

Mutual co-authors in cluster

Author profile →

2 papers

Recent·Most cited

PARP14 is a PARP with both ADP-ribosyl transferase and hydrolase activities

N. Đukic, O. Stromland, D. Munnur, K. Zhu, M. Schuller, C. Chatrin, P. Kar, J. G. M. Rack, D. Baretic, H. Schüler, S. Wijngaarden, D. V. Filippov, S. Sanyal, R. Smith, D. Ahel, I. Ahel

This study identifies PARP14 as a dual-function enzyme with ADP-ribosyl transferase and hydrolase activities, revealing its role in antiviral responses and substrate specificity.

bioRxiv · Jun 25, 2023Cell Biology

Iterative computational design and crystallographic screening identifies potent inhibitors targeting the Nsp3 Macrodomain of SARS-CoV-2

S. Gahbauer, G. J. Correy, M. Schuller, M. P. Ferla, Y. U. Doruk, M. Rachman, T. Wu, M. Diolaiti, S. Wang, J. Neitz, D. Fearon, D. S. Radchenko, Y. Moroz, J. J. Irwin, A. R. Renslo, , J. S. Fraser

The paper computationally designs and experimentally validates potent inhibitors of the SARS-CoV-2 Nsp3 Macrodomain, identifying 160 ligands and 152 crystal structures with submicromolar affinity.

bioRxiv · Jun 27, 2022Biophysics