Age-dependent RGS5 loss in pericytes induces cardiac dysfunction and fibrosis in the heart
A. Tamiato, L. S. Tombor, A. Fischer, M. Muhly-Reinholz, L. R. Vanicek, B. N. Togru, J. Neitz, S. F. Glaser, M. Merten, D. Rodriguez Morales, J. Kwon, S. Klatt, B. Schuhmacher, S. Guenther, W. T. Abplanalp, , G. Luxan
This study shows that loss of RGS5 in pericytes with age leads to cardiac dysfunction and fibrosis by altering pericyte function and activating fibroblasts.
bioRxiv · Dec 8, 2023Physiology