T. Wu

Dynamic Regulation of Innate Lymphoid Cell Development During Ontogeny

This study investigates the developmental changes in innate lymphoid cell (ILC) subsets using scRNA-seq and differentiation assays, revealing distinct regulatory programs in fetal and adult stages.

Defensive symbiont genotype distributions are linked to parasitoid attack networks

The paper shows that Hamiltonella defensa genotype distributions in aphids align with shared parasitoids rather than host plants, indicating parasitoids drive symbiosis prevalence.

NRF2-dependent regulation of the prostacyclin receptor PTGIR drives CD8 T cell exhaustion

This study identifies the KEAP1-NRF2 pathway as a driver of CD8 T cell exhaustion by regulating the prostacyclin receptor PTGIR.

Epigenetic regulation of alveolar macrophage homeostasis by histone deacetylase 1 and 2

This study shows HDAC1 and HDAC2 are essential for alveolar macrophage homeostasis by suppressing Bim expression and co-regulating differentiation with LSD1.

A Conserved Inhibitory Interdomain Interaction Regulates DNA-binding Activities of Hybrid Two-component Systems in Bacteroides

The paper identifies a conserved inhibitory interdomain interaction in HTCSs that suppresses DNA-binding activity in Bacteroides until phosphorylation occurs.

LXA4 promotes the browning of white adipose through miR-133a-3p/SIRT1 pathway

This study shows LXA4 promotes white adipose browning and improves insulin resistance via the miR-133a-3p/SIRT1 pathway in mice.

Tension-induced adhesion mode switching: the interplay between focal adhesions and clathrin-containing adhesion complexes

This study investigates the spatiotemporal regulation of focal adhesions and clathrin-containing adhesion complexes in breast cancer cells, revealing their inverse relationship with membrane tension and distinct roles in cancer progression.

Cortical microinfarcts potentiate recurrent ischemic injury through NLRP3-dependent trained immunity

This study shows that microinfarcts in mice enhance recurrent stroke severity via NLRP3-dependent trained immunity in microglia.

Senescent cells impair fracture repair through elevating ubiquitin-proteasome system activity in aged mice.

This study shows senescent cells impair fracture repair in aged mice by increasing ubiquitination of PDGFRβ via TGFβ, suggesting a new therapeutic target.

A telomere-to-telomere genome assembly of Zhonghuang 13, a widely-grown soybean variety from the original center of Glycine max

This paper presents the first telomere-to-telomere genome assembly of the soybean cultivar Zhonghuang 13, resolving gaps and identifying novel genes and structural variations.

Gut microbial genomes with paired isolates from China signify probiotic and cardiometabolic effects

The paper presents a new microbial reference set with paired isolates from China, showing probiotic and cardiometabolic effects on hosts.

Vitamin D promotes DNase1L3 to degrade ecDNA and inhibit the malignant progression of hepatocellular carcinoma

This study shows vitamin D reduces ecDNA in hepatocellular carcinoma by stabilizing DNase1L3 via its transporter GC, leading to tumor suppression.

PTPN2 copper-sensing rapidly relays copper level fluctuations into EGFR/CREB activation and associated CTR1 transcriptional repression

The paper identifies PTPN2 as a copper sensor that modulates EGFR/CREB signaling and CTR1 transcriptional repression in response to copper level changes.

Systematic characterization of therapeutic vulnerabilities in Multiple Myeloma with Amp1q reveals increased sensitivity to the combination of MCL1 and PI3K inhibitors

Rho of plant GTPase MxROP1 regulates Fe deficiency responses by targeting Zinc Ribbon 3 in apple rootstock

This study identifies MxROP1 as a regulator of Fe deficiency responses in apple rootstock by interacting with ZR3.1 and modulating its stability and interaction with MxbHLH39.

BRD4 directs mitotic cell division by inhibiting DNA damage

This study shows BRD4 is essential for normal cell growth by regulating cell cycle genes and preventing DNA damage during replication and mitosis.

T-cell inflammation is prognostic of survival in patients with high-risk neuroblastoma enriched for an adrenergic signature

The paper identifies T-cell inflammation (TCI) as a prognostic marker in high-risk neuroblastoma, showing improved survival in ADRN tumors but not MES tumors.

Automated cell annotation in multi-cell images using an improved CRF_ID algorithm

This paper improves the CRF_ID algorithm for multi-cell imaging in C. elegans, enhancing its accuracy and generalizability beyond whole-brain imaging.

Molecular Evolution and Interaction of 14-3-3 Proteins with H+-ATPases in Plant Abiotic Stresses

This paper reviews the roles of 14-3-3 proteins and H+-ATPases in plant abiotic stress responses and analyzes their molecular evolution across species.

Assessing Genetic Diversity in Critically Endangered Chieniodendron hainanense Populations within Fragmented Habitats in Hainan

This study assesses genetic diversity in critically endangered Chieniodendron hainanense populations using GBS and SNP methods, finding limited diversity and weak genetic differentiation.

Isolation of Actinomyces cricetomyis sp. nov from orocervicofacial abscesses of African giant pouched rats (Cricetomys ansorgei)

The paper isolates and characterizes a novel Actinomyces species from abscesses in African giant pouched rats.

Temporal colonization of the gut microbiome in neonatal Bos taurus at single nucleotide resolution

This study tracks microbial colonization in neonatal calves and identifies genetic links between microbes and host metabolites affecting health and growth.

Early microbial intervention reduces diarrhea while improves later milk production in newborn calves

This study shows that early microbial intervention in newborn calves reduces diarrhea and improves later milk production by altering gut microbiome composition and metabolite profiles.

Immunogenetic metabolomics revealed key enzymes that modulate CAR-T metabolism and function

The paper identifies ADA as a metabolic regulator that enhances CAR-T cell function and tumor clearance through improved metabolism and reduced exhaustion.

Comprehensive Multi-omics Analysis Reveals the Core Role of Glycerophospholipid Metabolism in Rheumatoid Arthritis Development

This study identifies glycerophospholipid metabolism as a key factor in rheumatoid arthritis development through multi-omics analysis of gut microbiota, metabolites, and gene expression.

POLCAM: Instant molecular orientation microscopy for the life sciences

POLCAM provides a fast, simplified method for single-molecule orientation microscopy using polarization cameras, enabling rapid molecular anisotropy analysis in biological samples.

An ULK1/2-PXN mechanotransduction complex suppresses breast cancer cell migration

This study identifies ULK1/2 as regulators of PXN-dependent mechanotransduction in breast cancer cells, showing their role in inhibiting migration by modulating focal adhesion assembly.

Single fluorogen imaging reveals distinct environmental and structural features of biomolecular condensates

This study uses single-fluorogen imaging to reveal that biomolecular condensates have hydrophobic internal environments and spatially inhomogeneous molecular organization.

Conformationally responsive dyes enable protein-adaptive Differential Scanning Fluorometry

This paper introduces paDSF, a protein-adaptive Differential Scanning Fluorometry method that improves compatibility with proteins and expands observable processes.

Endometrial adhesion G protein-coupled receptors are dynamically expressed across the menstrual cycle and expression is altered by ovarian stimulation

The paper investigates ADGR gene expression across the menstrual cycle and shows their expression is altered by ovarian stimulation.